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URL: https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2023/nejm_2023.388.issue-8/nejmra2215289/20230221/images/img_xlarge/nejmra2215289_f2.jpeg
URL2: https://www.nejm.org/doi/full/10.1056/NEJMra2215289